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In another study, the combined administration of deferasirox and vitamin D3 mitigated ion induced-injury by decreasing the levels of pro-inflammatory cytokines (IL-1β/IL-6/TNF-α), oxidative stress (MDA/H 2 O 2 ) and apoptotic markers, but increasing IL-10, GSH, SOD1, catalase and GPX4 levels in rats (101)

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Epithelial tight junction is a critical intestinal barrier, and its disruption could leak toxic substances from the gut into blood circulation and cause systemic injury